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| 1916 |
| | | New Zealand surgeon Harold Gillies sets up a plastic surgery unit at Aldershot, a British military base | |
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| 1918 August |
| | | A world-wide pandemic of influenza breaks out, and within the space of a year kills 30 million people | |
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| 1920 |
| | | New Zealand surgeon Harold Gillies publishes a pioneering text book, Plastic Surgery of the Face | |
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| c. 1921 |
| | | The first traces are found of a major but entirely forgotten civilization in the Indus valley | |
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| 1921 |
| | | Alfred Adler, in Vienna, opens the first of many child-guidance clinics | |
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| 1922 |
| | | Linus Pauling, a graduate student at the California Institute of Technology, begins theoretical work on the nature of the chemical bond | |
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| 1922 |
| | | Howard Carter exposes a flight of steps in the Valley of the Kings and comes to a barrier bearing the name Tutankhamun | |
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| 1922 |
| | | Canadian physiologists Frederick Banting and Charles Best isolate insulin from the pancreas for the treatment of diabetes | |
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| 1923 |
| | | Sigmund Freud proposes a new interpretation of the mind in his book The Ego and the Id | |
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| 1924 |
| | | US astronomer Edwin Hubble proves that the nebula Andromeda is vastly further away than other stars and can only be a separate galaxy | |
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